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Gonorrhoea is one of the most common sexually transmissible infections in men who have sex with men MSM. Gonorrhoea rates have increased substantially in recent years. There is concern that increasing gonorrhoea prevalence will increase the likelihood of worsening antibiotic resistance in Neisseria gonorrhoeae. A recent randomised controlled trial RCT demonstrated that a single-dose of mouthwash has an inhibitory effect against oropharyngeal gonorrhoea. We are conducting the first RCT to evaluate whether daily use of mouthwash could reduce the risk of acquiring oropharyngeal gonorrhoea.
Rectal infection with Chlamydia trachomatis is one of the most common bacterial sexually transmissible infections among men who have sex with men MSM with diagnosis rates continuing to rise. However, there are increasing concerns about treatment failure with azithromycin. We are conducting the first randomised controlled trial RCT to compare treatment efficacy of azithromycin versus doxycycline for the treatment of rectal chlamydia in MSM.